Research Interests
Inflammatory Skin Diseases
Advances in understanding dermatologic conditions has given us new markers for understanding why one treatment works and another does not, but we have not yet bridged the translational divide between the evidence and how to apply this information in the real world. Inflammation is known to be a complex biological response that usually happens as a reaction to harmful stimuli (pathogens, irritants, etc.), injuries, or genetics and affects all tissues within the body.
Skin Cancer
In SIIRG, we are interested in managing skin complications in cancer patients while they receive treatment including skin rashes, graft versus host disease, and skin cancer. We also have a special interest in rheumatologic diseases and autoimmunity that can be caused by some forms of immune based chemotherapeutics.
Molecular Genetics & Biomarkers
We utilize proteomics, immunoassays and next generation sequencing technologies to investigate genetic and molecular alterations associated with skin disease and treatment response. Using genetic and molecular data obtained from patients, we predict and develop new therapeutics for a variety of skin disorders. Our ultimate goal is to utilize molecular information to manage and treat patients with dermatologic disorders.
Digital Health
Our group is interested in the burgeoning digital health field as there are opportunities to improve patient triage by closing the gap to reach dermatologists. AI and mobile applications hold the potential to detect suspicious lesions or recommend biopsy. These technologies have the ability to provide unobtrusive detection methods for collecting patient data. From onset, engaging dermatologies with digital health can help to serve as a way to implement the technology in a careful patient centric approach to care.
Research Tools
Dermatopathology
Stanford’s Dermatopathology Service reviews cases for both primary diagnosis and consultation/ second opinion by board certified pathologists and dermatopathologists. Our wide spectrum of services includes routine sectioning, special histochemistry and immunohistochemistry, immunofluorescence, and horizontal sections for evaluation of alopecia.
SCG Informatics Cluster
The SCG Informatics Cluster resources are available for use by labs engaged in genetics and bioinformatics research. The SCG Cluster is designed and managed to support large memory, serial and single node threaded applications as well as applications and workflows that require many small files. Other clusters on campus are available for more general-purpose or HPC oriented user communities, see the Stanford Research Computing Center for more details.
STAnford Research Repository (STARR)
The STAnford Research Repository, or STARR, is Stanford Medicine's approved resource for working with clinical data for research purposes. The STARR IRB permits the collection and aggregation of all clinical data generated at Stanford for care purposes, and articulates the formal approval process each research project must follow in order to obtain and work with this data for research purposes.
The Human Immune Monitoring Center (HIMC)
HIMC provides standardized, state-of-the-art immune monitoring assays at the RNA, protein, and cellular level, as well as archiving, reporting, and data mining support for clinical and translational studies. In partnership with the research community, we also work to test and develop new technologies for immune monitoring.
Stanford genomics
The Stanford Genomics provides services for high-throughput sequencing, single-cell assays, gene expression and genotyping studies utilizing microarray and real-time PCR, and related services to researchers within the Stanford community and to other institutions. Stanford Genomics customers have 24/7 access to instruments, equipment and software. The facility supports Agilent, Illumina, Nimblegen and other microarray and sequencing platforms. In addition to proving full support for the above, Stanford Genomics can also print custom microarrays utilizing cDNA, oligonucliotides, proteins, peptides, antibodies, cell lysates, siRNAs, and other types of materials.
